Synthesis and biological evaluation of novel N-substituted 1H-dibenzo[a,c]carbazole derivatives of d
Monday, December 9, 2013
Posted by: Amanda Young
Synthesis and biological evaluation of novel N-substituted 1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential antimicrobial agents
W Gu, C Qiao, SF Wang, Y Hao, TT Miao - Bioorganic
& Medicinal Chemistry Letters, 2013
A series of new N-substituted 1H-dibenzo[a,c]carbazole derivatives were synthesized from dehydroabietic acid, and their structures were characterized by IR, 1H
NMR and HRMS spectral data. All compounds were evaluated for their
antibacterial and antifungal activities against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens) and three fungi (Candida albicans, Candida tropicalis and Aspergillus niger)
by serial dilution technique. Some of the synthesized compounds
displayed pronounced antimicrobial activity against tested strains with
low MIC values ranging from 0.9 to 15.6 μg/ml. Among them, compounds 6j and 6r exhibited potent inhibitory activity comparable to reference drugs amikacin and ketoconazole.
22 and neuroprotective activities. 23. Dehydroabietic acid (DHA,1), a natural
occurring diterpene resin acid, can be extracted from Pinus rosin or commercial
disproportionated rosin. Many derivatives of DHA have ...